Bone mineral density was measured to assess whether the patients with premonopausal hypogonadism, comprised of 19 patients with hypogonadotropic hypogonadism (HH), 55 with premature ovarian failure (POF), 23 with hyperprolactinemia (HPLN), and 8
with
Sheehan's syndrome. All aged from 20 to 39, were associated with some decrease in regional bone mass compared with that of 63 normal-cycling control women matched with age and sex. Measurement of bone mineral density was carried out using Dual
photon
absorptiometry at four sites; femur neck, ward's triangle, trochanter and spine (L2-14).
Bone mineral density at all four sites were significantly decreased in patients with HH (p<0.01), POF (p<0.01). In hyperprolactinemic patients, the decrease in bone mass was significant at femur neck and Ward's triangle (p<0.05). The patients
with
POF
were noted to be associated with significant bone loss when their duration of amenorrhea exceeded one year. In this study, the degree of loss of bone mass and the affected sites seemed to be different depending on the various types of
hypogonadism
and
POF was noted have caused the appearance of loss of bone mass earlier than other thpes of hypogondism we experienced.
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